Capsule filling with a nozzle dispenser (ND) has been studied extensively (Jones, 2001; Newton, 2012) and is one of the most important technologies used in the pharmaceutical industry today. The nozzles are available in sizes that fit the capsule diameter (from 00 to 5) and dispense a certain amount of powdered powder into the capsule.
The amount of powder that can be processed by the smallest nozzle (size 5) ranges from 40 mg to 80 mg (depending on the density of the powder formulation). You can also buy used capsule filling machine online.
Some new and promising drugs require powder handling in smaller amounts: 5 mg to 20 mg. The immediate solution is to expand the use of nozzle dispensers (by reducing the diameter of the nozzle) and use the functions already available for this technology: High-performance and highly automated weight control for quality control of each capsule.
However, this requires an understanding of the design space for smaller diameter nozzles and a review of the effect of process parameters and powder properties on capsule quality. The miniaturization of the nozzles is expected to affect the process performance and quality of the capsules.
In this study, Experimental Design (DOE) was used as part of the Quality by Design approach to investigate the effect of technological parameters and material properties of three small nozzles on fill weight and weight variability. Capsule filling machines (Labby, MG2) with one ND were used.